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Study Report - GWAS of type II diabetes mellitus (HGVST3)| HGVbaseG2P identifier | HGVST3 | |||||||||||||||
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| Study name | GWAS of type II diabetes mellitus | |||||||||||||||
| Phenotype(s) tested | Type II diabetes |
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| Study design | Case and control | |||||||||||||||
| Genotype Platforms |
Affymetrix 500K GeneChip | |||||||||||||||
| Abstract | Summary-level data and analysis results of Type 2 Diabetes in a Scandinavian Cohort imported from the DGI Consortium project. New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases. | |||||||||||||||
| Submission information |
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| Cross-references |
DGI - Broad website |
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| Background | Not supplied | |||||||||||||||
| Objectives | Not supplied | |||||||||||||||
| Key results | Not supplied | |||||||||||||||
| Conclusions | Not supplied | |||||||||||||||
| Reason for study size | Not supplied | |||||||||||||||
| Study power | Not supplied | |||||||||||||||
| Sources of bias | Not supplied | |||||||||||||||
| Limitations | Not supplied | |||||||||||||||
| Acknowledgements | Not supplied | |||||||||||||||
| Other citations |
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, LUND University, and Novartis Institutes of BioMedical Research et al
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels Science 2007 Jun 1;316(5829):1331-6 |
